Regulation of microglial responses after pediatric traumatic brain injury: exploring the role of SHIP-1.

Erskine Chu,Richelle Mychasiuk,Tabitha R F Green,Akram Zamani,Larissa K Dill,Rishabh Sharma,April L Raftery,Evelyn Tsantikos,Margaret L Hibbs,Bridgette D Semple

Frontiers in neuroscience（2023）

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摘要

Together, evidence does not support SHIP-1 as an essential regulator of brain microglial morphology, brain immune responses, or the extent of tissue damage after moderate-severe pediatric TBI in mice. However, our data suggest that reduced SHIP-1 activity induces a greater inflammatory response in the hippocampus chronically post-TBI, warranting further investigation.

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microglial responses,pediatric traumatic brain injury,traumatic brain injury

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