Design of layer-by-layer lipid-polymer hybrid nanoparticles to elicit oral bioavailability of buspirone hydrochloride

Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 +/- 4.2nm and zeta potential of -30.5 +/- 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates. [GRAPHICS]