Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells.

HomeCirculationVol. 148, No. 20Studying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextStudying Long QT Syndrome Caused by NAA10 Genetic Variants Using Patient-Derived Induced Pluripotent Stem Cells Nadjet Belbachir, Yiyang Wu, Mengcheng Shen, Sophia L. Zhang, Joe Z. Zhang, Chun Liu, Bjorn C. Knollmann, Gholson J. Lyon, Ning Ma and Joseph C. Wu Nadjet BelbachirNadjet Belbachir Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. Search for more papers by this author , Yiyang WuYiyang Wu Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, NY (Y.W., G.J.L.). Vanderbilt Memory & Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN (Y.W.). Search for more papers by this author , Mengcheng ShenMengcheng Shen https://orcid.org/0000-0001-7037-6159 Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. Search for more papers by this author , Sophia L. ZhangSophia L. Zhang Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. Search for more papers by this author , Joe Z. ZhangJoe Z. Zhang Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. Search for more papers by this author , Chun LiuChun Liu https://orcid.org/0000-0002-8242-3896 Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. Greenstone Biosciences, Palo Alto, CA (C.L., J.C.W.). Search for more papers by this author , Bjorn C. KnollmannBjorn C. Knollmann https://orcid.org/0000-0003-4956-9735 Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (B.C.K.). Search for more papers by this author , Gholson J. LyonGholson J. Lyon Gholson J. Lyon, MD, PhD, 1050 Forest Hill Rd, Staten Island, NY 10314-6399, Email E-mail Address: [email protected] Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, NY (Y.W., G.J.L.). Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island (G.J.L.). Biology PhD Program, Graduate Center, City University of New York (G.J.L.). Search for more papers by this author , Ning MaNing Ma Ning Ma, PhD, 188 Kaiyuan Ave, Science City, Huangpu District, Guangzhou, Guangdong 510530, China, Email E-mail Address: [email protected] https://orcid.org/0000-0002-1775-2992 Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. School of Basic Medical Sciences, Guangzhou Laboratory, Guangzhou Medical University, China (N.M.). The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, China (N.M.). Search for more papers by this author and Joseph C. WuJoseph C. Wu Correspondence to: Joseph C. Wu, MD, PhD, 265 Campus Dr G1120B, Stanford, CA 94304, Email E-mail Address: [email protected] https://orcid.org/0000-0002-6068-8041 Stanford Cardiovascular Institute, Stanford, CA (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.). Division of Cardiology, Department of Medicine (N.B., M.S., S.L.Z., J.Z.Z., C.L., N.M., J.C.W.), Stanford University School of Medicine, CA. Department of Radiology (J.C.W.), Stanford University School of Medicine, CA. Greenstone Biosciences, Palo Alto, CA (C.L., J.C.W.). Search for more papers by this author Originally published13 Nov 2023https://doi.org/10.1161/CIRCULATIONAHA.122.061864Circulation. 2023;148:1598–1601FootnotesFor Sources of Funding and Disclosures, see page 1601.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Joseph C. Wu, MD, PhD, 265 Campus Dr G1120B, Stanford, CA 94304, Email joewu@stanford.eduNing Ma, PhD, 188 Kaiyuan Ave, Science City, Huangpu District, Guangzhou, Guangdong 510530, China, Email ma_ning@gzlab.ac.cnGholson J. Lyon, MD, PhD, 1050 Forest Hill Rd, Staten Island, NY 10314-6399, Email gholson.j.lyon@opwdd.ny.govREFERENCES1. Wu Y, Lyon GJ. NAA10-related syndrome.Exp Mol Med. 2018; 50:85. doi: 10.1038/s12276-018-0098-xCrossrefGoogle Scholar2. Wu Y. Toward Precision Medicine: From Clinical Genomics to iPSC Disease Modeling (Publication No. 10281516) [Doctoral dissertation, Stony Brook University]. ProQuest Dissertations Publishing; 2017. http://hdl.handle.net/11401/77611Google Scholar3. Casey JP, Stove SI, McGorrian C, Galvin J, Blenski M, Dunne A, Ennis S, Brett F, King MD, Arnesen T, et al. NAA10 mutation causing a novel intellectual disability syndrome with long QT due to N-terminal acetyltransferase impairment.Sci Rep. 2015; 5:16022. doi: 10.1038/srep16022CrossrefMedlineGoogle Scholar4. Rope AF, Wang K, Evjenth R, Xing J, Johnston JJ, Swensen JJ, Johnson WE, Moore B, Huff CD, Bird LM, et al. Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency.Am J Hum Genet. 2011; 89:28–43. doi: 10.1016/j.ajhg.2011.05.017CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails November 14, 2023Vol 148, Issue 20 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.061864PMID: 37956223 Originally publishedNovember 13, 2023 KeywordsiPSCrare diseaseCav1.2 calcium channelNAA10long QTPDF download Advertisement SubjectsArrhythmiasStem CellsSudden Cardiac DeathTranslational Studies