Advanced Techniques for Quantification of N-nitrosodiethanolamine in Cosmetic Products

Cosmetics are daily chemical industrial products used for cleaning, health care, and beauty purposes. Sometimes these products are contaminated by heavy metals, unwanted chemicals, and other dangerous substances that can lead to environmental pollution and cause various diseases and physiological side effects in humans. N-nitrosodiethanolamine compounds are among the unwanted contaminants created during the production of cosmetic products. In recent years, various qualitative and quantitative analytical methods have been used for detection of nitrosamine compounds in many products, and various techniques were developed to address the limitations of previous methods. This study reviewed approaches developed to detect N-nitrosodiethanolamine compounds, including microextraction techniques and application of nanotechnology in order to design accurate analytical methods and high sensitivity nanosensors to overcome the limitations of current methods and designing practical and cost-effective systems.