Trajectories of social function in patients with first-episode schizophrenia: Analysis of data from a 10-year follow-up study

Background: Patients with schizophrenia may have diverse functional outcomes. However, the long-term functional trajectories of patients with first -episode schizophrenia (FES) are unclear. Methods: We extracted data from the Chinese First -Episode Schizophrenia Trial, a 10 -year prospective study of antipsychotic-naive patients with FES. We applied K means cluster modelling to longitudinal data on the social function of patients with FES and examined associations of the empirically derived trajectories with baseline clinical characteristics of the 10 -year follow-up. Outcomes: Three distinct functional trajectories emerged: improving -favorable (39.3%), improving -poor (17.8%) and improving -stable (42.9%). All three trajectories demonstrated Personal and Social Performance (PSP) score improvement in the first six months. The improving -poor trajectory demonstrated PSP score decline during the second six months and thereafter, while PSP scores in the other two trajectories were mainly stable during the same period. Patients in the improving -favorable trajectory had higher baseline PSP scores than those in the improving -poor trajectory (OR=0.904 [0.852, 0.961], p < 0.05) and the improving -stable trajectory (OR=0.870 [0.825, 0.918], p < 0.001) and were more likely to be female than those in the improving -stable trajectory (OR=2.699 [1.030, 7.074], p < 0.05). Conclusions: Patients with FES demonstrated varied long-term functional recovery profiles. The first year, especially the second half of the first year, is a key period for social function interventions that improve long-term functional outcomes. Male patients and patients with poor baseline function may particularly benefit from such interventions.