Repurposing Dried Blood Spot Device Technology to Examine Bile Acid Profiles in Human Dried Fecal Spot Samples.

Stool analysis in remote settings can be challenging, as the samples must be stored at −80°C and transported on dry ice for downstream processing. Our work indicates that dried fecal spots (DFS) on Capitainer quantitative DBS (qDBS) devices can be stored and shipped at ambient temperature and yields the same bile acid profiles as traditional samples. This approach has broad applications for patient home testing and sample collection in rural communities or resource-limited countries.