SIRT1, a Target of Mir-708-3p, Alleviates Fluoride-Induced Neuronal Damage Via Remodeling Mitochondrial Network Dynamics.

•• SIRT1 activation exerted protective roles against fluoride-induced cognitive defects.•• SIRT1 activation restored fluoride-caused defective mitochondrial network dynamics.•• SIRT1 was targeted directly by miR-708-3p.•• MiR-708-3p mediated the neurotoxic process of fluoride via directly targeting SIRT1.•SIRT1, a target of miR-708-3p, alleviates fluoride-induced neuronal damage via remodeling mitochondrial network dynamics.