Pneumatocele-induced pneumothorax after COVID-19 infection in a 45-day-old infant

Throughout the literature, many pathologic lung lesions and complications following coronavirus disease 2019 (COVID-19) infection have been reported including pneumatocele formation which could potentially lead to pneumothorax development. This case report discusses the clinical course of a 45-day-old male with respiratory distress, whose condition worsened over time. Investigations revealed elevated COVID-19 immunoglobulin G (IgG) antibodies with negative COVID polymerase chain reaction (PCR) accompanied by radiologic evidence of pneumatocele formation, which was further complicated by pneumothorax. The clinical presentation of the patient was consistent with post-COVID infection but he had no history of contact with a sick individual which prompted further investigation of the source of the infection. Upon reviewing the history of the mother, symptoms consistent with COVID-19 around 32 weeks of pregnancy were revealed, which raises the possibility of maternal-fetal exchange of COVID-19 infection. This article presents the youngest reported patient with COVID-19 pneumonia that led to pneumatocele formation.