Antibacterial, anti-inflammatory, rapid hemostasis, and accelerated repair by multifunctional metal-organic frameworks fibrous scaffolds for diabetic wounds

Excessive inflammation, bacterial infection, persistent bleeding, and wound exudate accumulation are common in diabetic wounds, impeding cell proliferation and disturbing tissue remodeling, making it difficult for diabetic wounds to heal. The rapid hemostasis and reduction of bacterial infection, as well as the excessive infiltration of inflammatory factors, serve as key strategies for diabetic wound healing. In this study, Taxifolin (TAX) was loaded onto cyclodextrin metal-organic frameworks (CD-MOFs), which were subsequently loaded into polycaprolactone (PCL) scaffolds via electrostatic spinning to construct multifunctional electrospun fibrous membranes (EFMs) with antimicrobial, anti-inflammatory, hemostatic, and wound exudate-absorbent properties. The resulting EFMs exhibited a hydrophilic surface, which facilitated wound adhesion and enhanced its hemostatic properties. By aggregating the wound exudate and triggering a cascade release of TAX, bacterial infection in the wound was reduced, decreasing the expression of inflammatory factors. This also promoted collagen deposition, vascular regeneration, and myofibroblast contraction and migration and facilitated the remodeling and repair of the wound tissue. These results demonstrated that designed fibrous scaffolds could effectively accelerate the repair process of diabetic mice, providing a new strategy for the treatment of diabetic wounds.