Nowe aspekty choroby trzewnej — epidemiologia, diagnostyka, objawy

Lack of knowledge about clinical symptoms and celiac disease diagnosis may lead to a significant delay in diagnosis. There was a definite progress in the diagnostic possibilities of celiac disease. Four gastroenterological organizations such as: the American College of Gastroenterology (ACG), the European Society of Pediatric Gastroenterology, Hepatology and Nutrition, the World Gastroenterological Association and The British Society of Gastroenterology propose the diagnosis of visceral disease based on halotyping, small intestine biopsy and serum antibody determination. In addition, ESPGHAN (European Society of Pediatric Gastroenterology, Hepatology and Nutrition, World Gastroenterological Association) suggests that in young patients a non-invasive diagnostic method may be used, a tTG IgA titer , which is 10 times above the upper limit of normal, endomysial antibodies, and the HLA DQ2 or DQ8 halotype. According to the Oslo definition, the following classification should be used: classical, non-classical, symptomatic, asymptomatic, potential, recurrent. Celiac disease may manifest itself in specific clinical symptoms such as: diarrhea, flatulence, deficiency or weight loss, malabsorption leading to deficiencies of vitamins and micronutrients, for example anemia, lactose intolerance, and non-specific disease, e.g. infertility, irregular monthly cycle, or problems with maintaining a pregnancy. It also happens that the disease is asymptomatic. The clinical picture of celiac disease in the elderly (≥ 65) and younger (18–64) is ver y similar. The aim of the work is to present the most impor tant information about epidemiology, diagnostics and symptoms of celiac disease.