Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.

Carla Mariner-Llicer, Belén Saavedra Cervera,Edson Mambuque,Neide Gomes,Shilzia Munguambe,Luis Villamayor,Irving Cancino-Muñoz,Manuela Torres-Puente, Dinis Nguenha,Durval Respeito, Gustavo Tembe,Mariana G López,Iñaki Comas,Alberto L García-Basteiro

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2024）

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摘要

Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate detection of antimicrobial-resistance in the country.

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