Safety of bempedoic acid in patients at high cardiovascular risk and with statin intolerance

Harold E. Bays,LeAnne T. Bloedon,Grace Lin,Heather A. Powell,Michael J. Louie,Stephen J. Nicholls,A. Michael Lincoff,Steven E. Nissen

Journal of Clinical Lipidology（2023）

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摘要

•Long term use of bempedoic acid is well tolerated.•Exposure adjusted cholelithiasis rate with bempedoic acid is 0.6/100 patient years.•Patients with gout at baseline reported similar rates of gout.•Reports of tendinopathies were comparable between groups.

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关键词

Bempedoic acid,ATP-citrate lyase inhibitor,CLEAR Outcomes Study,Hypercholesterolemia,Low-density lipoprotein cholesterol,Safety

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