Adhesion G protein-coupled receptor G2 accelerates the proliferation of cancer cells by promoting the formation of CDK4/CCND1

Abstract Gastric cancer is a common malignant tumor in humans. Analysis of clinical data of gastric cancer revealed that adhesion G protein-coupled receptor G2 (ADGRG2), endoplasmic reticulum oxidoreductase 1β, lactate dehydrogenase B and chromosome 1 open reading frame 115 were abnormally highly expressed in gastric cancer. ADGRG2 was not only highly expressed in gastric cancer tissues, but was also associated with poor prognosis in patients with gastric cancer. Numerous oncogenes and tumor suppressor genes are directly involved in the regulation of the cell cycle. ADGRG2 was shown to promote cell proliferation by promoting the G1/S transition. ADGRG2 did not affect the expression of CDK4 or cyclin D1 (CCND1), but was found to affect the cell cycle by promoting the formation of the cell cycle-dependent complex CDK4/CCND1, thereby promoting cell proliferation, and affecting the formation and development of gastric cancer.