Ternary Coordination Compounds of Copper(II) with Glycine and 2,2'- bipyridine: Synthesis, Structural Characterization, Magnetic and Biological Properties

Three new coordination compounds of copper(II) with glycine (HGly) and 2,2'-bipyridine (bipy) were synthesized by solution-based and mechanochemical methods: [Cu(Gly)(H2O)(bipy)][Cu(Gly)(SO4)(bipy)] center dot 6H(2)O (1a center dot 6H(2)O), [Cu(Gly)(H2O)(bipy)](2)SO4 (1b), [Cu(Gly)( H2O) (bipy)](2)SO4 center dot H2O (1b center dot H2O). The amount of water in the reaction mixture influenced the product of crystallization. All compounds were characterized by X- ray diffraction methods and form 1D infinite chains or 2D sheets of complex ions connected by p-interactions. Compounds 1a center dot 6H(2)O and 1b were characterized by X-band electron spin resonance (ESR) spectroscopy and the values of g-tensors for Cu(II) ions were determined. Compounds 1a center dot 6H(2)O and 1b showed pronounced antiproliferative activity toward a panel of six human cell lines. The most impared was HepG2 cell line at 10(-5) mol dm(-3) concentration (74.5 % reduction of cell growth) followed by moderate activity toward KATO III, Caco-2, MDA-MB- 231, PANC-1 and MRC-5 cells at 10-4 mol dm(-3) concentration of compounds 1a center dot 6H(2)O and 1b. Generally, both compounds express similar antiproliferative effect on evaluated cells.