Life Histories of Myeloproliferative Neoplasms Inferred from Phylogenies

Brief summary: This study performed whole-genome sequencing (WGS) of 1013 clonal haematopoietic cell colonies from 12 adult patients aged 20–81 years with myeloproliferative neoplasms, a form of blood cancer. They identified 580 133 somatic mutations and used these to reconstruct haematopoietic clonal histories. Key somatic (i.e. non-germline) driver mutations were estimated to have occurred early in life, including fetal life and early childhood.