O012 / #761 inhibition of pain-related mtor proteins using differential target multiplexed scs in an animal neuropathic pain model

The mammalian target of rapamycin (mTOR) protein complexes are involved in neuropathic pain by regulating neuroinflammation. Modulation of mTOR pathways, and associated phosphorylation, might disrupt neuropathic pain. Spinal cord stimulation (SCS) with differential target multiplexed programming provided better analgesia than low rate SCS (LR) in an animal model of neuropathic pain. Differential Target Multiplexed SCS acts by modulating biological processes that were perturbed by neuropathic pain.