Albumin and caffeine -loaded nanofiber for topical wound healing

Abstract Background Intravenous albumin administration increases blood circulation and enhances wound healing. Topical caffeine can induce vascularization and the formation of blood vessels on the skin. The purpose of this work is to explore for the first time the effect of topical albumin and caffeine on wound healing in rat models. Methods This work aimed to develop albumin and caffeine-loaded nanofibers by the electrospinning method and to evaluate their topical effect on wound healing. Nanofiber formation was assessed by SEM and considered using FT-IR spectroscopy. Results The therapeutic activity of topical albumin and caffeine was investigated on a full-thickness excision skin model. Results indicate faster healing of wounds covered with albumin. Albumin alone or in combination with caffeine effectively reduced the exposed wound area. Data show that daily albumin-loaded wound dressing displayed good healing properties and enhanced wound closure rate. Conclusion These findings may indicate the successful application of the sauce as a promising tool in wound healing therapy.