Cartilage Lacuna‐Inspired Microcarriers Drive Hyaline Neocartilage Regeneration (Adv. Mater. 30/2023)

Cartilage Tissue Engineering In article number 2212114, Wenguo Cui, Qi Gu, Ming-Zhu Zhang, and co-workers introduce novel cartilage lacuna-inspired microcarriers with geometric constraints to repress chondrocyte dedifferentiation by inhibiting Wnt signaling. The biomimetic microcarriers display favorable cytocompatibility and drive robust hyaline chondrocyte-derived neocartilage formation. This study paves the way for deciphering the geometrical insights into the interactional mechanism of mechanotransduction in regulating cell fate.