Supplementary Figure 3 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma

PDF file - 3.4MB, Inhibition of S6 phosphorylation in APC-/PTEN- murine ovarian tumors by rapamycin in vivo. Immunoblot of lysates from primary tumor tissues from mice treated for 4 weeks with vehicle (V1, 2, 3), 1 mg/kg (R1) or 4 mg/kg (R4) rapamycin. Levels of phosphorylated and total Akt and S6, and �-actin are shown. Lower panels show IHC staining of primary tumor tissues for pS6 in vehicle (left) and rapamycin (right) treated murine ovarian tumors.