Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice

We show for the first time that loss of Gdf15 exacerbates mortality, lung injury, and the phenotype of the arrest of alveolarization in the developing lung with loss of female-sex advantage in Gdf15 −/− mice. We also highlight the distinct pulmonary transcriptomic response in the Gdf15 −/− lung including pathways related to macrophage recruitment and activation.