Should an Attempt at Debulking Grossly Metastatic Endometrial Cancer be Undertaken?

Surgical debulking for metastatic cancer is a cornerstone of treatment for gynecologic cancers. Endometrial cancer is rarely diagnosed in advances stages; thus, the role of surgical cytoreduction and the development of best practice remain controversial. The physiologic principles of cytoreductive surgery, retrospective data on stage IV endometrial cancer surgical survival outcomes, and extrapolating from randomized prospective data from advanced stage ovarian cancer provide a compelling rationale for tumor debulking surgery in order to provide the best possible outcomes for advanced endometrial cancer patients.