The Relationship of FDG PET-SUVm and Glucose Metabolism and Contribution to Early-Stage Non-Small Cell Lung Cancer Survival

K. Kernstine, B. M. Faubert, Q. N. Do, T. J. Rogers, C. T. Hensley, L. Cai, J. R. Torrealba, D. H. Oliver, A. Kandathil, R. E. Lenkinski, C. R. Malloy, J. K. Waters, S. I. Reznik,M. E. Jessen, R. J. Deberardinis

Journal of Thoracic Oncology（2023）

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摘要

Enhanced glucose uptake in tumors is imaged by 18F-2-deoxyglucose-positron emission tomography (FDG-PET). In patients with non-small cell lung cancer (NSCLC), the FDG-PET maximum standard uptake value (SUVm) correlates with advanced stage and poor outcome. However, FDG is not readily metabolized by tumors. Therefore, how SUVm relates to glucose metabolism is poorly understood. This study measures glycolytic tumor metabolism in vivo to investigate the relationship.

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关键词

Lung Cancer,Positron Emission Tomography,Glycolysis

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