Mp40-15 the diagnostic value of psma pet/ct in men with newly diagnosed international society of urological pathology grade group 3 intermediate-risk prostate cancer

You have accessJournal of UrologyCME1 Apr 2023MP40-15 THE DIAGNOSTIC VALUE OF PSMA PET/CT IN MEN WITH NEWLY DIAGNOSED INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY GRADE GROUP 3 INTERMEDIATE-RISK PROSTATE CANCER Marinus J. Hagens, Wietske I. Luining, Auke Jager, Maurits Wondergem, Maarten L. Donswijk, Zing Cheung, Daniela E. Oprea-Lager, André N. Vis, Pim J. van Leeuwen, and Henk G. van der Poel Marinus J. HagensMarinus J. Hagens More articles by this author , Wietske I. LuiningWietske I. Luining More articles by this author , Auke JagerAuke Jager More articles by this author , Maurits WondergemMaurits Wondergem More articles by this author , Maarten L. DonswijkMaarten L. Donswijk More articles by this author , Zing CheungZing Cheung More articles by this author , Daniela E. Oprea-LagerDaniela E. Oprea-Lager More articles by this author , André N. VisAndré N. Vis More articles by this author , Pim J. van LeeuwenPim J. van Leeuwen More articles by this author , and Henk G. van der PoelHenk G. van der Poel More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003278.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Metastatic screening using prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is increasingly being adopted in urological practice. PSMA PET/CT has been shown to be of diagnostic value in men with high-risk prostate cancer (PCa), however, this has still not been demonstrated for men with International Society of Urological Pathology (ISUP) grade group (GG) 3 intermediate-risk PCa. This study aims to determine the diagnostic value of PSMA PET/CT within this subgroup of newly diagnosed ISUP GG3 intermediate-risk PCa patients. METHODS: Patients with newly diagnosed ISUP GG3 intermediate-risk PCa, in whom a PSMA PET/CT was performed as a primary staging modality, were retrospectively studied. PSMA PET/CT scans were performed in several diagnostic centers and revised/reported by expert nuclear medicine physicians within two high-volume PCa centers by expert nuclear medicine physicians. A multivariate logistic regression analysis, taking into account clinical, biochemical, pathological and radiological variables, was performed to identify potential independent predictors for metastatic disease on PSMA-PET/CT. RESULTS: In total, 396 men with newly diagnosed ISUP GG3 intermediate-risk PCa were studied. Metastatic disease was observed in 37/396 (9.3%) men, of whom 29/396 (7.3%) had molecular imaging locoregional lymph node metastases (miN1) and 16/396 (4.0%) had distant metastases (miM1). A radiological tumor stage ≥T3 on MRI (OR: 2.70 [95% CI: 1.25-5.87], p=0.01) and more than 75% positive prostate biopsies (OR: 5.00 [95% CI: 1.47-16.93], p=0.01) were found to be independently associated with metastatic disease on PSMA PET/CT (Table 1). CONCLUSIONS: Given that metastatic disease was observed in nearly one in ten men with biopsy ISUP GG3 intermediate-risk PCa, PSMA PET/CT is considered to be of diagnostic value within this population. Further stratification using the radiological tumor stage and the percentage of positive prostate biopsies could aid in identifying those patients at risk of having metastatic disease on PSMA PET/CT. Source of Funding: No funding was obtained © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e550 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Marinus J. Hagens More articles by this author Wietske I. Luining More articles by this author Auke Jager More articles by this author Maurits Wondergem More articles by this author Maarten L. Donswijk More articles by this author Zing Cheung More articles by this author Daniela E. Oprea-Lager More articles by this author André N. Vis More articles by this author Pim J. van Leeuwen More articles by this author Henk G. van der Poel More articles by this author Expand All Advertisement PDF downloadLoading ...