Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma (Adv. Sci. 1/2023)

Mechanism of Superenhancer-Driven LncRNA Accelerating Lipid Metabolism In article number 2204711, Li Peng and co-workers reveal the mechanism of superenhancer-related lncRNA functioning in lipid metabolism. It can be simulated by the accelerating vehicle. LncRNA FASRL is transcriptionally driven by USF1 via its superenhancer. FASRL binding to ACACA, a fatty acid synthesis rate-limiting enzyme, increases lipid accumulation to exacerbate HCC.