ALDH2 polymorphism, alcohol intake and the attributable burden of cancer in East Asia: systematic review, meta-analysis, and modeling study

Carmen S. Ng,Xin Jiong Ong,Minnie Au,Yan Ho Lau,Harley H.Y. Kwok,Jianchao Quan

Annals of Epidemiology（2023）

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摘要

•Current studies greatly underestimate the risk of cancer due to alcohol.•Increased risk of esophageal and pharyngeal cancer in drinkers with ALDH2 mutation.•Dose-response curves adjusted for ALDH2*2 effects had higher risks of cancers.•Higher burden of alcohol-attributable cancer in ALDH2 prevalent populations.

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关键词

ALDH2,PAF,DALYs,GBD,GHO,IHME,PRISMA,PROSPERO

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