Use of larotrectinib in a pediatric patient with NTRK‐rearranged spindle cell neoplasm and subsequent recurring bone fracture

Pediatric Blood & CancerEarly View e30679 LETTER TO THE EDITOR Use of larotrectinib in a pediatric patient with NTRK-rearranged spindle cell neoplasm and subsequent recurring bone fracture Minji Kim, Minji Kim Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of KoreaSearch for more papers by this authorKyung Taek Hong, Corresponding Author Kyung Taek Hong [email protected] orcid.org/0000-0002-8822-1988 Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of Korea Correspondence Kyung Taek Hong, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, Republic of Korea. Email: [email protected]Search for more papers by this authorHyun Jin Park, Hyun Jin Park Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of KoreaSearch for more papers by this authorBo Kyung Kim, Bo Kyung Kim Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of KoreaSearch for more papers by this authorYun Jeong Lee, Yun Jeong Lee Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of KoreaSearch for more papers by this authorJung Yoon Choi, Jung Yoon Choi Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of KoreaSearch for more papers by this authorYoung Hun Choi, Young Hun Choi Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorSung-Hye Park, Sung-Hye Park Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorHan-Soo Kim, Han-Soo Kim Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorHyoung Jin Kang, Hyoung Jin Kang orcid.org/0000-0003-4671-0449 Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of Korea Wide River Institute of Immunology, Hongcheon, Republic of KoreaSearch for more papers by this author Minji Kim, Minji Kim Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of KoreaSearch for more papers by this authorKyung Taek Hong, Corresponding Author Kyung Taek Hong [email protected] orcid.org/0000-0002-8822-1988 Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of Korea Correspondence Kyung Taek Hong, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, Republic of Korea. Email: [email protected]Search for more papers by this authorHyun Jin Park, Hyun Jin Park Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of KoreaSearch for more papers by this authorBo Kyung Kim, Bo Kyung Kim Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of KoreaSearch for more papers by this authorYun Jeong Lee, Yun Jeong Lee Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of KoreaSearch for more papers by this authorJung Yoon Choi, Jung Yoon Choi Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of KoreaSearch for more papers by this authorYoung Hun Choi, Young Hun Choi Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorSung-Hye Park, Sung-Hye Park Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorHan-Soo Kim, Han-Soo Kim Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of KoreaSearch for more papers by this authorHyoung Jin Kang, Hyoung Jin Kang orcid.org/0000-0003-4671-0449 Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea Seoul National University Cancer Research Institute, Seoul, Republic of Korea Wide River Institute of Immunology, Hongcheon, Republic of KoreaSearch for more papers by this author First published: 16 September 2023 https://doi.org/10.1002/pbc.30679Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Drilon A, Laetsch TW, Kummar S, et al. Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med. 2018; 378(8): 731-739. 2Marchetti A, Ferro B, Pasciuto MP, Zampacorta C, Buttitta F, D'Angelo E. NTRK gene fusions in solid tumors: agnostic relevance, prevalence and diagnostic strategies. Pathologica. 2022; 114(3): 199-216. 3 WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours. WHO Classification of Tumours Series. 5th ed. Vol. 3. International Agency for Research on Cancer; 2020. 4Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives. Pathologica. 2021; 113(2): 70-84. 5Laetsch TW, DuBois SG, Mascarenhas L, et al. 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Roles of neurotrophins in skeletal tissue formation and healing. J Cell Physiol. 2018; 233(3): 2133-2145. Early ViewOnline Version of Record before inclusion in an issuee30679 ReferencesRelatedInformation