Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis

We present a multicomponent reaction catalyzed by a Pd/amine/Brønsted acid ternary system. The approach facilitates the synthesis of substituted 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters through the assembly of two in situ generated active intermediates.