58 Measuring Origin-to-terminus Ratios with Droplet Digital Polymerase Chain Reaction to Estimate Bacterial Growth Rate in Cystic Fibrosis Sputum

with untreated controls) were observed for CF-370 ( p ≤0 .001); the antibiotic comparators were largely inactive against persister cells (<1log 10 CFUs/mL fewer than in untreated controls).Similar results were obtained with other pathogens tested.Conclusions: Lysin CF-370 is active against a range of gram-negative pathogens, including those associated with airway infections in CF.There was no cross-resistance with antibiotics, and CF-370 was active against persister forms of all pathogens tested.These findings suggest that CF-370 may have the potential to address the unmet need for treatments for pulmonary exacerbations of CF caused by MDR gram-negative pathogens.