Changes of Naturally Occurring Antibodies Against ASC in Healthy Chinese Population

Background To explore the changes of in human plasma Naturally occurring antibodies against ASC (NAbs-ASC) in healthy Chinese population . Methods A total of 97 young, 99 middle-aged and 108 elderly subjects were recruited from the Health Management Department of Daping Hospital, Army Medical University. The medical history data of the three groups and plasma levels of NAbs-ASC were compared to analyze changes of their and correlation in aging . Results Naturally occurring antibodies against ASC were present in human plasma and a one-way ANOVA yielded significantly lower plasma levels of NAbs-ASC in the elderly group relative to the young (2421.15 vs 2849.26, p < 0.001) and middle-aged groups (2421.15 vs 2878.44, p < 0.001); plasma levels of NAbs-ASC in the young group were not statistically different from those in the middle-aged group (2849.26 vs 2878.44, p = 0.576). Spearman's correlation analysis showed a negative correlation between age and plasma NAbs-ASC levels (r=-0.265, p < 0.001). Conclusion NAbs-ASC is widely present in human plasma and reduced in the plasma of elderly people and negatively correlated with age.