The factors affecting psychological health and life satisfaction of patients with gestational trophoblastic neoplasia

Abstract Background: Patients with gestational trophoblastic neoplasia (GTN) have significant anxiety, depression, sexual dysfunction, and fertility problems according to pieces of previous studies. This study aims to explore the factors influencing the psychological health and life satisfaction of patients with GTN. Methods: In a single-center, cross-sectional study, 79 cases of GTN patients treated and followed up in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Xi’an Jiaotong University were invested to complete the general information questionnaire, mainly including age, marriage, career, household income and fertility pressures, Hospital Anxiety and Depression Scale (HADS), and Life Satisfaction Scale (SWLS) in addition to the collection of clinical information such as diagnosis and treatment. Student’s t -test, Mann-Whitney test, chi-square and Fisher's exact test, binary logistic regression, and linear regression were used in this study based on Statistical Package for the Social Sciences (SPSS) Results: A total of 79 GTN patients were enrolled, 44.3% and 20.3% of them were anxious and depressed, respectively. Multivariate analyses revealed that only the interval from index pregnancy (months) ( ρ = 0.04) and surgical treatment ( ρ < 0.001) were the key features related to anxiety status. While the place of residence (especially in the foreign province) ( ρ = 0.02) exhibited vita consequences when it comes to depression status in GTN patients. Furthermore, a positive correlation had been found in the scores between HADS-A and HADS-D ( r = 0.77, ρ < 0.001), while the analogous relationship didn’t exist in HADS-A ( r = 0.09, ρ = 0.45) and HADS-D ( r = 0.06, ρ = 0.61) with SWLS. Conclusions: Our work herein suggests that various characteristics, especially the status of treatment, surgical treatment, and place of residence were central to psychological complaints such as anxiety, depression as well as satisfaction in GTN patients.