A Biocompatible Horner-Wadsworth-Emmons (HWE) Reaction Triggered by a Bioorthogonal Proximity-Induced Platform
Chinese Chemical Letters(2024)
摘要
Here, we present a novel bioorthogonal platform that enables precise positioning of attached moieties in close proximity, thereby facilitating the discovery and optimization of biocompatible reactions. Using this platform, we achieve a Horner-Wadsworth-Emmons (HWE) reaction under physiological conditions, generating a fluorophore in situ with a yield of up to 93%. This proximity platform should facilitate the discovery of various types of biocompatible reactions, making it a versatile tool for biomedical applications.
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关键词
Biocompatible reactions,Horner-Wadsworth-Emmons reaction,Bioorthogonal reactions,Tetrazines,Proximity effects
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