Aroyl-isothiocyanate/isoselenocyanate as precursors to afford novel cis-3-aroyl-thiourea/urea-ββ-lactams: Design, synthesis, docking and biological evaluation

Herein, a novel synthetic methodology was devised to synthesize cis-3-aroyl-urea-β-lactams by reacting aroyl isoselenocyanates with cis-3-amino-β-lactams in a THF:H2O mixture (9:1). This synthetic approach eliminates the previous requirement for the...