Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Maarten te Groen,Lauranne Derikx,L Van Lierop,Bauke Ylstra,Frank Hoentjen,Irıs D. Nagtegaal,Femke Simmer

Inflammatory Bowel Diseases（2023）

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摘要

Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

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关键词

inflammatory bowel disease patients,prior colorectal neoplasia,pouch neoplasia

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