Correction: Leucine 434 is essential for docosahexaenoic acid–induced augmentation of L-glutamate transporter current

Leucine 434 is essential for docosahexaenoic acid–induced augmentation of L-glutamate transporter currentJournal of Biological ChemistryVol. 299Issue 1PreviewAstrocytic excitatory amino acid transporter 2 (EAAT2) plays a major role in removing the excitatory neurotransmitter L-glutamate (L-Glu) from synaptic clefts in the forebrain to prevent excitotoxicity. Polyunsaturated fatty acids such as docosahexaenoic acid (DHA, 22:6 n-3) enhance synaptic transmission, and their target molecules include EAATs. Here, we aimed to investigate the effect of DHA on EAAT2 and identify the key amino acid for DHA/EAAT2 interaction by electrophysiological recording of L-Glu–induced current in Xenopus oocytes transfected with EAATs, their chimeras, and single mutants. Full-Text PDF Open Access Funding and additional information should include a Grant-in-Aid from Hoansha Foundation and should read as follows. Funding and additional information—This work was partly supported by a Grant-in-Aid for Young Scientists from the Ministry of Education, Science, Sports, and Culture, Japan (KAKENHI 18700373, 21700422, 17K08330), a Grant for the Program for Promotion of Fundamental Studies in Health Sciences of NIBIO, Japan, a grant for Research on Risks of Chemicals, a Labor Science Research Grant for Research on New Drug Development from the MHLW, Japan, a Research Grant on Regulatory Harmonization and Evaluation of Pharmaceuticals, Medical Devices, Regenerative and Cellular Therapy Products, Gene Therapy Products, and Cosmetics from AMED, Japan (iPSC Non-Clinical Experiments for Nervous System Project: iNCENS), a Grant-in-Aid from Hoansha Foundation awarded to K. S.