Esophageal biomechanics assessed by impedance planimetry (EndoFLIP TM) in healthy subjects and in patients with eosinophilic esophagitis. Normality values

active eosinophilic esophagitis is associated with esophageal caliber, distensibility, and motility changes that might be reversed with treatment.to study esophageal diameter, distensibility and contractility in healthy subjects compared to patients with eosinophilic esophagitis both before and after treatment.a cuasi-experimental study; EndoFLIP™ was used to analyze the esophageal body and EGJ in all 3 groups, and a program was designed to obtain esophageal diameter, distensibility, and contractility values.we included 10 healthy volunteers (24-61 years, 6 men) and 9 patients with eosinophilic esophagitis (21-52 years, 7 men). The esophagogastric junction distensibility index was 5.07 mm2/Hg in the control subjects, 2.40 mm2/Hg in the subjects with eosinophilic esophagitis before treatment, and 2.46 mm2/Hg in the latter subjects after treatment; the distensibility plateau was 20.02 mm, 15.43 mm, and 17.41 mm, respectively, and the diameter was 21.90 mm, 17.73 mm, and 18.30 mm, with significant differences (p < 0.05) except between control subjects and patients after treatment (p = 0.079). Repetitive antegrade contractions developed in 90% of control subjects, 66.7% of eosinophilic esophagitis patients before treatment, and 88.9% of the latter after treatment (p > 0,05).esophago-gastric junction distensibility index, distensibility plateau, and diameter values were higher in controls than in patients, although 6 weeks of treatment seems a short period for observing significant changes in esophageal biomechanics. Repetitive antegrade contractions are the predominant pattern in healthy subjects and in eosinophilic esophagitis. We provide normality values for esophageal biomechanics as measured by impedance planimetry in our setting.