A Fetal Rat Model of Ventricular Noncompaction Caused by Intrauterine Hyperglycemia.

•We introduce a novel fetal rat model of ventricular noncompaction (NVM) caused by intrauterine hyperglycemia, induced by a combination of a high-fat diet and STZ injections.•Intrauterine hyperglycemia or elevated RA can result in NVM features in embryos, accompanied by endoplasmic reticulum stress in cardiomyocytes.•An adverse intrauterine developmental environment plays a significant role in the onset of NVM.