Two New Bibenzyl Methylglucosides As SIRT3 Activators Obtained Through Microbial Transformation.
Journal of Asian natural products research(2023)
摘要
Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4 '-O-(4 ''-O-methyl-beta-D-glucopyranosyl)-dihydroresveratrol (4 '-O-MG DHRSV, 1) and 3-O-(4 ''-O-methyl-beta-D-glucopyranosyl)-dihydroresveratrol (3-O-MG DHRSV, 2) on the basis of spectroscopic methods. They showed moderate SIRT3 agonistic activity, and compound 2 exhibited the best deacetylation of 406.63% at 10 mu M. The activity of 2 increased by 3.12-fold compared with that of DHRSV, since 2 performed better in molecular docking assay (GScore -8.445). [GRAPHICS]
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关键词
Bibenzyls,microbial transformation,Beauveria bassiana,methylglucosylation,SIRT3 agonist
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