Piperacillin Pharmacokinetics and Pharmacodynamics in Paediatric Patients Who Received High Frequency Piperacillin/Tazobactam Dosing Intra-Operatively

Piperacillin/tazobactam (PTZ) is a broad-spectrum antibiotic, typically dosed every six hours (q6h). Guidelines recommend dosing PTZ every 2 hours (q2h) intra-operatively for complex abdominal surgeries, including liver transplant. The data supporting the guidelines for intra-operative dosing are sparse and the pharmacokinetics/pharmacodynamics (PK/PD) of q2h dosing has never been studied by simulation or in humans. We compared PK/PD parameters of high-frequency intra-operative dosing and q6h post-operative dosing in critically ill children.