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A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer.

Clinical cancer research an official journal of the American Association for Cancer Research(2024)

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摘要
Advanced differentiated thyroid cancer that is resistant to radioactive iodine therapy may become responsive with a unique treatment combination of chloroquine and vorinostat. This treatment was demonstrated in cellular and animal models of thyroid cancer to inhibit endocytosis of the plasma membrane-bound iodine transporter, NIS, and restore iodine uptake. See related article by Read et al., p. 1352.
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