The evolutionary trajectories of specialized metabolites towards antiviral defense system in plants

Viral infections in plants pose major challenges to agriculture and global food security in the twenty-first century. Plants have evolved a diverse range of specialized metabolites (PSMs) for defenses against pathogens. Although, PSMs-mediated plant-microorganism interactions have been widely discovered, these are mainly confined to plant-bacteria or plant-fungal interactions. PSM-mediated plant-virus interaction, however, is more complicated often due to the additional involvement of virus spreading vectors. Here, we review the major classes of PSMs and their emerging roles involved in antiviral resistances. In addition, evolutionary scenarios for PSM-mediated interactions between plant, virus and virus-transmitting vectors are presented. These advancements in comprehending the biochemical language of PSMs during plant-virus interactions not only lay the foundation for understanding potential co-evolution across life kingdoms, but also open a gateway to the fundamental principles of biological control strategies and beyond. Graphical Abstract The putative co-evolutionary triad of plant metabolites (PSM) mediated interactions between plant, viruses and their insect vectors. This dynamic trio is depicted through the interplay represented by pink and green arrows, signifying the PSM mediated bidirectional interactions occurring between the virus, the host plant, and the vector.