Efficient, Concise, and Chemoselective Synthesis of 1H-Benzo[f]indole-4,9-dione with 4-Hydroxycoumarin Substituent via a One-Pot Three-Component Reaction

Extensive studies on the biological activities of several quinone-fused heterocycles have confirmed their outstanding antitumor activity. Therefore, a new family of 1H-benzo[f]indole-4,9-dione derivatives with the 4-hydroxycoumarin substitution was prepared by a high-yield, one-pot, concise three-component reaction between arylglyoxals, 4-hydroxycoumarin, and 2-aminonaphthalene-1,4-dione derivatives under reflux in EtOH. This efficient protocol showed chemoselectivity in addition to facile operation procedure and easy purification.