HOCl sensitivity associates with a reduced p53 transcriptional network and calreticulin expression in 25 human cancer cell lines

•25 human cell lines were compared for their sensitivity to HOCl-induced oxidative 2 stress, showing up to 5-fold differences•Transcriptomic analysis of unstressed cells and gene expression correlation revealed 4 the p53 network to be associated with HOCl treatment resistance•A screening of 33 cell surface markers revealed calreticulin and nitric oxide synthase 6 2 expression to be associated with HOCl treatment resistance