Older age associated with better antidepressant response to H1-coil transcranial magnetic stimulation in female patients

Background: TMS is increasingly used to treat depression, but predictors of treatment outcomes remain unclear. We assessed the association between age and TMS response given inconsistent prior reports limited by small sample size, heterogeneity, outdated TMS parameters, lack of assessment of H1 -coil TMS, and lack of an a priori hypothesis. We hypothesized that older age would be associated with better treatment response based on trends in recent large exploratory analyses. Methods: We conducted a naturalistic retrospective analysis of patients (n = 378) ages 18-80 with depression (baseline Quick Inventory of Depressive Symptomatology Self -Report (QIDS-SR) > 5) who received 29-35 sessions of TMS between 2014 and 2021. Response was assessed using percent reduction of QIDS-SR. The relationship between percent response or remission and age group was assessed using the chi-square test. Results: 85 % of patients received the standard protocol of H1 -coil TMS to the left DLPFC. Percent response and remission rates for the entire study sample increased with age (response: p = .026; remission: p = .0023). This finding was stronger in female patients (response: p = .0033; remission: p = .00098) and was not observed in male patients (response: p = .73; remission: p = .26). This was confirmed in a sub -analysis of patients who only received the standard protocol with the H1 -coil for the entire treatment course. Limitations: Naturalistic retrospective analysis from one academic center. Conclusions: Older age is associated with a better antidepressant response to H1 -coil TMS in female patients. This was demonstrated in a hypothesis -driven confirmation of prior exploratory findings in a large sample size with a homogeneous data collection protocol across all participants.