Highly Enantioselective Ir-Catalyzed Hydrogenation of Pyrazolo[1,5‑a]pyrimidine for the Synthesis of Zanubrutinib
The Journal of Organic Chemistry(2024)
摘要
A highly enantioselective catalytic reduction of pyrazolo[1,5-a]pyrimidine to zanubrutinib has been realized by the Ir/(R)-t-Bu-FcPhox complex. This chiral product could be obtained in up to >99% ee in the asymmetric transformation without any other additives, providing a new route for the asymmetric synthesis of zanubrutinib.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要