Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities

Hans J.C.T. Wessels,Purva Kulkarni,Maurice van Dael,Anouk Suppers,Esther Willems,Fokje Zijlstra,Else Kragt,Jolein Gloerich,Pierre-Olivier Schmit,Stuart Pengelley, Kristina Marx,Alain J. van Gool,Dirk J. Lefeber

Journal of Advanced Research（2023）

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摘要

•Plasma glycoproteomics provides broad and reproducible coverage for clinical applications.•Chemometric analyses demonstrates great potential of glycoproteomics for biomarker applications.•Site-specific glycosylation changes delineate glycobiology processes underlying disease.•Bioinformatic analyses of disease samples enable integral interpretation of glycoproteomes.•Glycosylation changes can be site-specific on single protein molecules depending on disease.

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关键词

Glycosylation,Glycoproteomics,Blood plasma,Congenital disorders of glycosylation,Clinical applications

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