Synergy of shaped-induced enhanced Raman scattering to improve surface-enhanced Raman scattering signal in the thiram molecule detection

Herein, we explore the combined effect of Shaped-Induced Enhanced Raman Scattering (SIERS) and SurfaceEnhanced Raman Scattering (SERS) for detecting thiram molecules. We fabricated V-shaped microchannels on a silicon (100) substrate through a standard lithography and etching process. The analysis of SIERS@SERS was performed for Si -V substrates modified with AuNRs with different thiram concentrations, 10-7 to 10-10 mol/L. The spectra were collected for different regions of the Si -V substrates, i.e., in the inside, edge, between (flat top), and far from Si -V (coffee-ring AuNRs aggregation) to assess the performance of Si -V microchannels obtained. The IDMAP statistical projection reveals a higher silhouette coefficient of 0.91 for the inside of Si -V, indicating a more excellent spectral reproducibility with closer relative intensities. The device platform used in this study stands out as a robust option for commercial sensors, demonstrating exceptional sensitivity in detecting a diverse range of molecules, even at low concentrations.