A kelch beta propeller featuring as a G beta structural mimic: reinventing the wheel?

New genetic and protein interaction data suggest that G protein alpha subunits may have partners with primary sequences that are quite divergent. How this is achieved may be through the adoption of similar structures, the beta propeller, by both proteins containing WD-40 repeats and kelch domains. Gettemans et al. describe results in yeast that suggest that kelch-domain proteins may serve as previously unrecognized beta subunits in the heterotrimeric G protein complex.