Difelikefalin for Hemodialysis Patients with Pruritus in Japan.

Ichiei Narita,Yoshiharu Tsubakihara,Naoko Takahashi,Toshiya Ebata,Takuma Uchiyama, Masaya Marumo,Shota Okamura, Fumitake Gejyo

NEJM evidence（2023）

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摘要

Difelikefalin for Hemodialysis Patients with PruritusDifelikefalin has been developed for the treatment of pruritus in hemodialysis patients. In this randomized trial of 230 Japanese patients with moderate-to-severe pruritus and undergoing maintenance hemodialysis, difelikefalin (0.5 μg/kg three times per week intravenously for 4 weeks) significantly reduced itching and improved quality of life.

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