Fractal Changes of the Retinal Microvasculature in Syphilitic Uveitis

OCULAR IMMUNOLOGY AND INFLAMMATION(2024)

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摘要
PurposeTo quantify chorioretinal microvascular damage and recovery post-treatment in patients with acute syphilitic posterior placoid chorioretinitis (ASPPC) using fractal dimension (FD).MethodsRetrospective cohort study of patients with serologically confirmed syphilitic uveitis. We obtained optical coherence tomography angiography (OCTA) scans at baseline and follow-up after intravenous penicillin treatment and computed FD of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using ImageJ.ResultsWe enrolled seven patients with ASPPC (11 eyes), and 17 control subjects (34 eyes). Pre-treatment averages of FD-SCP, FD-DCP, and FD-CC were: 1.672 (+/- 0.115), 1.638 (+/- 0.097), and 1.72 (+/- 0.137); post-treatment: 1.760 (+/- 0.071), 1.764 (+/- 0.043), and 1.898 (+/- 0.047). After treatment FD-CC increased in all 11 eyes with an average of 0.163 (p = 0.003); FD-DCP increased in 10 (91%) eyes with an average of 0.126 (p = 0.003); and FD-SCP increased in seven (64%) eyes with an average of 0.089 (p = 0.059). Compared to the post-treatment FD values in the syphilitic group, controls had similar FD-SCP (p = 0.266), FD-DCP (p = 0.078), and FD-CC (p = 0.449).ConclusionsCC and DCP are mostly affected in ASPPC with minimal changes in the SCP. All vascular layers FD recovered after completing antibiotic treatment.
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关键词
Choriocapillaris,fractal dimension,imaging biomarker,OCTA,syphilitic uveitis
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