Visible-Light-Promoted Intermolecular -Acyl Difunctionalization of Alkenes via Oxidative Radical-Polar Crossover
ORGANIC LETTERS(2023)
摘要
A visible-light-induced beta-acyl difunctionalization of alkenes with acyl oxime esters and various nucleophiles was developed to achieve molecular complexity from readily available raw materials via oxidative radical-polar crossover. A variety of nucleophiles, including NH-sulfoximines, indoles, indazole, and trimethoxybenzene, were all effectively applicable to the sustainable reaction system. The novel synthetic strategy features mild reaction conditions, a broad substrate scope (39 examples), easy scale-up, and excellent regioselectivity.
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